Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Relating Multi-step and Single-Step Microprocessor Correctness Statements

A diverse collection of correctness statements have been proposed and used in microprocessor verification efforts. Correctness statements have evolved from criteria that match a single step of the implementation against the specification to seemingly looser, multi-step, criteria. In this paper, we formally verify conditions under which two categories of multi-step correctness statements logical...

متن کامل

single-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate

in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...

15 صفحه اول

Single-locus tests of microsatellite evolution: multi-step mutations and constraints on allele size.

We evaluate some common simulation procedures as well as a recently developed likelihood method used for testing hypotheses regarding microsatellite evolution. Results from simulated data revealed that the tests for the detection of multi-step mutations in general have some power, whereas tests for the presence of constraints on the repeat number have only very limited power. The tests were app...

متن کامل

Application of single step genomic BLUP under different uncertain paternity scenarios using simulated data

The objective of this study was to investigate the application of BLUP and single step genomic BLUP (ssGBLUP) models in different scenarios of paternity uncertainty with different strategies of scaling the G matrix to match the A22 matrix, using simulated data for beef cattle. Genotypes, pedigree, and phenotypes for age at first calving (AFC) and weight at 550 days (W550) were simulated using h...

متن کامل

Single - Step Ada for

Low-density parity-check (LDPC propagation (BP) algorithm achieve a remar close to the Shannon limit at reasonable de Conventionally, each iteration in decoding p steps, the horizontal step and the vertical ste efficient implementation of the adaptive offse algorithm for decoding LDPC codes using the is proposed. Furthermore, the performan algorithm compared with belief-propagation investigated...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: eLife

سال: 2021

ISSN: 2050-084X

DOI: 10.7554/elife.64116